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Originally known as amfebutamone, bupropion is a prescription medication primarily used as an antidepressant and smoking cessation aid. It has become a widely used treatment for depression, smoking cessation, and even ADHD.

In 2022, it was the 21st most prescribed medication in the United States, with more than 25 million prescriptions. It has also now earned itself a spot on the World Health Organization’s list of essential medicines.

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