Case Study

The Italian division of Novartis approached I Holland and local agent Vis Viva with a sticking issue on an anti-epileptic drug in the form of a coated tablet. Novartis reported a strong sticking/picking problem causing the press to be stopped several times during manufacture for cleaning and maintenance of the punches, which resulted in production downtime.

In this case study, a prediction model is used in conjunction with an examination of a tablet profile to resolve sticking issues.