PRODUCTION PROBLEMS

Tablet production problems can occur in many ways and lead to significant press downtime. Below we look at three common issues along with their possible solutions. There are many other challenges that may need to be addressed so please get in touch with us if yours is not covered here and let us help you increase your productivity.

Sticking

Probably the biggest production challenge faced by tablet manufacturers today, sticking is where the granulation adheres to the punch tip face causing costly wastage, reduced yield and unwanted press downtime.

 

Capping & Lamination

Laminar separation within of the tablet body or removal of the upper tablet cup can occur at any time during tablet compaction or any of the other downstream processes causing unusable tablets and unhappy customers.

 

Tablet Contamination

Presenting significant problems contamination can be the cause of quality rejects and low yields. Contamination usually presents itself in the form of black spots or mottled surfaces. Clearly product appearance is important for end-user perception and encourages brand loyalty.

Want a free TSAR≈PREDICT? Get in touch.

Our service team are happy to help.

Get In Touch

Production Solutions

{C45BF86A-2FD1-4416-A0E9-47FF8621A5CE}_1_thumb

PharmaGrade Steels

A complex problem like sticking requires a specialist solution. I Holland have the largest range of punch and die coatings on the market designed to meet the challenges of almost any formulation. When coupled with our unique statistical model TSAR~Predict, we can solve even the stickiest of situations.

Bellows Image

Bellows & Drip Cups

One solution to contamination is to use bellows or drip cups in conjunction with a seal groove on your tablet punch. This will prevent lubrication from entering into finished product. 

Steel_sml01

PharmaGrade Steels

Capping and lamination can be caused by many factors but one potential solution is to use specialist tooling steels to prevent die ringing and allow for optimised press force as well as improving wear resistance in general and extending overall tooling life.

Case Study - Solve Production Problems

The Italian division of Novartis approached I Holland and local agent Vis Viva with a sticking issue on an anti-epileptic drug in the form of a coated tablet. 

 

 

Tablet sticking is one of the most common problems in tablet manufacture. This buildup of granule on the punch tip face causes tablet press downtime and reduced tablet output. It has a negative effect on tablet appearance and often results in the removal of tablet tooling from production for regular cleaning and maintenance, as experienced by Novartis. 

www.tablettingscience.com

Site by Lowaire

en English
af Afrikaanssq Albanianam Amharicar Arabichy Armenianaz Azerbaijanieu Basquebe Belarusianbn Bengalibs Bosnianbg Bulgarianca Catalanceb Cebuanony Chichewazh-CN Chinese (Simplified)zh-TW Chinese (Traditional)co Corsicanhr Croatiancs Czechda Danishnl Dutchen Englisheo Esperantoet Estoniantl Filipinofi Finnishfr Frenchfy Frisiangl Galicianka Georgiande Germanel Greekgu Gujaratiht Haitian Creoleha Hausahaw Hawaiianiw Hebrewhi Hindihmn Hmonghu Hungarianis Icelandicig Igboid Indonesianga Irishit Italianja Japanesejw Javanesekn Kannadakk Kazakhkm Khmerko Koreanku Kurdish (Kurmanji)ky Kyrgyzlo Laola Latinlv Latvianlt Lithuanianlb Luxembourgishmk Macedonianmg Malagasyms Malayml Malayalammt Maltesemi Maorimr Marathimn Mongolianmy Myanmar (Burmese)ne Nepalino Norwegianps Pashtofa Persianpl Polishpt Portuguesepa Punjabiro Romanianru Russiansm Samoangd Scottish Gaelicsr Serbianst Sesothosn Shonasd Sindhisi Sinhalask Slovaksl Slovenianso Somalies Spanishsu Sudanesesw Swahilisv Swedishtg Tajikta Tamilte Teluguth Thaitr Turkishuk Ukrainianur Urduuz Uzbekvi Vietnamesecy Welshxh Xhosayi Yiddishyo Yorubazu Zulu
en English
af Afrikaanssq Albanianam Amharicar Arabichy Armenianaz Azerbaijanieu Basquebe Belarusianbn Bengalibs Bosnianbg Bulgarianca Catalanceb Cebuanony Chichewazh-CN Chinese (Simplified)zh-TW Chinese (Traditional)co Corsicanhr Croatiancs Czechda Danishnl Dutchen Englisheo Esperantoet Estoniantl Filipinofi Finnishfr Frenchfy Frisiangl Galicianka Georgiande Germanel Greekgu Gujaratiht Haitian Creoleha Hausahaw Hawaiianiw Hebrewhi Hindihmn Hmonghu Hungarianis Icelandicig Igboid Indonesianga Irishit Italianja Japanesejw Javanesekn Kannadakk Kazakhkm Khmerko Koreanku Kurdish (Kurmanji)ky Kyrgyzlo Laola Latinlv Latvianlt Lithuanianlb Luxembourgishmk Macedonianmg Malagasyms Malayml Malayalammt Maltesemi Maorimr Marathimn Mongolianmy Myanmar (Burmese)ne Nepalino Norwegianps Pashtofa Persianpl Polishpt Portuguesepa Punjabiro Romanianru Russiansm Samoangd Scottish Gaelicsr Serbianst Sesothosn Shonasd Sindhisi Sinhalask Slovaksl Slovenianso Somalies Spanishsu Sudanesesw Swahilisv Swedishtg Tajikta Tamilte Teluguth Thaitr Turkishuk Ukrainianur Urduuz Uzbekvi Vietnamesecy Welshxh Xhosayi Yiddishyo Yorubazu Zulu